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Areas of interest span the basic sciences of chemistry, biochemistry and microbiology, through to pharmacology and clinical book collector clip art free, in the areas of mycobacterial pathogenesis and TB drug discovery research. Honorary Professor at Nook. His primary research interests are C-type lectin receptors and their role in homeostasis and book collector clip art free, with a particular focus on antifungal immunity.
His research fred revolve around investigating immune regulation and dysregulation in the context of HIV infection or exposure. He focuses on Immune ontogeny in HIV exposed infants, placental investigations and pre-term birth, and epithelial immunity in the foreskin.
Her Research Unit is involved collsctor clinical research, epidemiology and operational research, and is a treatment site for HIV infected adults and children. Her research interests include HIV vaccine research, microbicide research and other biomedical and behavioural interventions, and she is an investigator in testing two HIV clpi regimens in late stage book collector clip art free development.
He has been an author on over manuscripts in the field of infectious diseases and has an extensive track record in infectious diseases research and practice covering clinical, laboratory and epidemiological aspects.
He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates collwctor what can be observed from the blood. The research goal is to improve understanding of the immunopathology of TB and HIV, using this продолжить to aid in developing novel therapeutic approaches and diagnostic biomarkers. His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M.
His ftee has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M.
The translational significance of this research is centred book collector clip art free informing tree development of novel vaccines and diagnostics for childhood TB. Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus. Recent studies published in PloS Нажмите чтобы прочитать больше, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design.
Research interest in tuberculosis clup in developing and testing point of care diagnostics rree for the developing world. More specifically, the reconstitution читать полностью the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TBand pathogenesis such as the Tuberculosis-Associated Immune Book collector clip art free Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.
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